Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 0.999 0.154 0.267
biological_process el 1648 0.0 0.999 0.167 0.275
biological_process ka 1648 0.0 1.0 0.422 0.476
biological_process rf 1648 0.0 0.999 0.154 0.267
cellular_component ct 184 0.0 1.0 0.464 0.394
cellular_component el 184 0.0 1.0 0.498 0.487
cellular_component ka 184 0.0 1.0 0.634 0.479
cellular_component rf 184 0.0 1.0 0.498 0.487
disease ct 1456 0.0 0.994 0.05 0.141
disease el 1456 0.0 0.992 0.048 0.142
disease ka 1456 0.001 1.0 0.128 0.302
disease rf 1456 0.0 0.994 0.049 0.14
genetic_interaction ct 1606 0.0 1.0 0.417 0.327
genetic_interaction el 1606 0.0 1.0 0.436 0.32
genetic_interaction ka 1606 0.0 1.0 0.84 0.364
genetic_interaction rf 1606 0.0 1.0 0.424 0.329
molecular_function ct 476 0.0 1.0 0.389 0.346
molecular_function el 476 0.0 1.0 0.438 0.409
molecular_function ka 476 0.0 1.0 0.772 0.415
molecular_function rf 476 0.0 1.0 0.428 0.414
pathway ct 555 0.001 1.0 0.276 0.346
pathway el 555 0.001 1.0 0.236 0.338
pathway ka 555 0.001 1.0 0.47 0.484
pathway rf 555 0.001 1.0 0.233 0.334
phenotype ct 1358 0.0 1.0 0.158 0.289
phenotype el 1358 0.0 1.0 0.12 0.249
phenotype ka 1358 0.0 1.0 0.291 0.44
phenotype rf 1358 0.0 1.0 0.115 0.242
protein_interaction ct 1657 0.0 1.0 0.07 0.163
protein_interaction el 1657 0.0 0.933 0.065 0.157
protein_interaction ka 1657 0.0 1.0 0.304 0.455
protein_interaction rf 1657 0.0 0.926 0.066 0.154

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 1.0 0.092 0.213
integration_mean_by_presence el 1676 0.0 0.992 0.045 0.136
integration_mean_by_presence ka 1676 0.0 1.0 0.109 0.298
integration_mean_by_presence rf 1676 0.0 0.943 0.041 0.112
mean ct 1676 0.0 1.0 0.088 0.211
mean el 1676 0.0 0.995 0.041 0.126
mean ka 1676 0.0 1.0 0.109 0.299
mean rf 1676 0.0 0.974 0.038 0.105

CDF plots of non integrated kernels

CDF plots of integrated kernels